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5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA)

Thus, applying an exogenous antioxidant that facilitates the maintenance of energy balance by enhancing brain energy metabolism is a therapeutic strategy that can be targeted for ameliorating the depressive-like phenotype in MS patients

Now, while some patients will absolutely need to take their thyroid medication, there are other modalities that can be used along with that medication to help the patient feel better long term

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