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NICE guidelines recommend hydroxocobalamin 1 mg intramuscularly three times weekly for 2 weeks (without neurological involvement) or on alternate days until no further improvement (with neurological symptoms)

This change of cell/tissue-specific expression was a result of a transgene containing the whole hGH gene and locus control region (LCR) in a fragment of human chromosome (Vakili et al., 2011, 2016)

Administration Considerations: Treatment approach, dosing, and frequency should be guided by a licensed clinician and dispensing pharmacy