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2.6 The impact of metabolic comorbidities: focusing on diabetes mellitus (DM) Pre-existing metabolic comorbidities, particularly DM, significantly elevate the risk and severity of POCD (40) (Figure 1)

They found that piperazine erastin significantly decreased the size and number of tumor foci in the liver of DEN/CCl4-induced mice and the volume of Bel-7402 cell xenografts, accompanied by reduced levels of GPX4 expression

was involved in designing the graphical abstract, discussion, figure preparation and writing the manuscript

The 6-week intervention demonstrated significantly greater efficacy compared to longer durations (6 weeks), which showed diminished effects