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10.1126/science.3381100 20 CoxB

It detects light signals produced by the release of pyrophosphate during nucleotide incorporation (68, 69)

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Although sometimes used synonymously, these terms actually describe technically different methods: Whitening : Generally means to decrease overall melanin production to achieve a lighter skin tone Brightening: Tends to improve luminosity and decrease dullness without necessarily altering skin colour Lightening: Tends to address specific dark spots or hyperpigmentation rather than overall tone Dr