glutathione lung cancer A study from the Birsoy lab showed that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience #YearInReview Decreased glutathione biosynthesis contributes to

Transitions from desensitized to resting/closed state require substantial conformational changes in LBD and the LBD-TM linkers In the gating cycle, post-desensitization, receptor needs to recover to a resting state, where the LBDs couple as 2-dimers for the next cycle of activation

These relatively non-selective PAMs include the neurosteroids [194, 195], tetrahydroisoquinoline series [196], thienopyrimidin-4-ones [197], tetrahydrobenzothiophene series [198], as well as two individual compounds: GNE-9278 [199, 200] and PTC-174 [97, 201]

Performance monitoring should be ongoing, not annual

Multicenter, prospective, observational study of chemotherapy-induced dysgeusia in gastrointestinal cancer