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75 A small controlled trial with 23 participants suffering from chronic tinnitus found tailor-made notched music training reduced activity in auditory brain regions and tinnitus loudness more effectively than placebo music training (with a varying notch in frequency range) or no treatment after six months and one year

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Researchers investigating DSIPs interaction with stress-response pathways may also find it of interest alongside peptides like Selank, which has its own preclinical record in anxiety-related animal models, and Epitalon, which has been studied in aging and antioxidant contexts
