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MiR-25 promotes autophagy and mediates sorafenib resistance by degrading FBXW7 mRNA and upregulating LC3-II protein levels [81]

Pietronigro, E

Besides, tumor-associated macrophage membranes (TAMMs) derived from primary tumors can block the interaction between TAMs and cancer cells by depleting CSF1 secreted by tumor cells in the TME, such as NPR@TAMM nanoparticle-mediated photodynamic immunotherapy formed by TAMM coated with conjugated photosensitizers can convert macrophages from an immunosuppressed M2-like phenotype to a more inflammatory M1-like phenotype thereby improving the anti-tumor immune response (67)

Individuals with severe deficiency might require a series of injections before experiencing significant changes in their mood or energy levels