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We therefore proceed to the cross-talk and potential synergy among Nrf2/ARE, PI3K/Akt, and NF-B

Correspondingly, ZD results in developmental retardation of children, delayed genital development and hypogonadism, skin disorders, hair loss, teratogenic effects, as well as weakened immune function, leading to an increased susceptibility to infections

The authors thank their colleagues in the Department of Oncology, the Department of Health Prevention and Care, Beijing Hospital and the Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, for supporting the review

At zinc doses higher than 50 mg/day, symptoms such as nausea, diarrhoea and abdominal discomfort may occur, whilst doses higher than 150 mg/day can adversely affect the bodys lipid profile and immune system