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Reduced levels of dopamine and norepinephrine are frequently observed, disrupting the brain's ability to maintain focus, process rewards, and regulate behavior
In contrast, the Grooved Pegboard Test, a commonly used measure of fine motor coordination and dexterity, demonstrates a broader dynamic range and has been shown to decline progressively with disease worsening, making it a more reliable response biomarker in longitudinal studies [512]
Antinociceptive mechanisms are not as well understood but the toxin may prevent glutamate release, and interfere with Na + channels, mechanosensitive receptors, and transient receptor potential ankyrin 1 (TRPA1) channels [123]