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Therefore, AKT signaling is required for suppression of Insig2a

Diabetes Care 43(5):940-7 2020 PMC7171946 Mather KJ, Bebu I, Baker C, Cohen RM, Crandall JP, DeSouza C, Green JB, Kirkman MS, Krause-Steinrauf H, Larkin M, Pettus J, Seaquist ER, Soliman EZ, Schroeder EB, Wexler DJ, Pop-Busui R, GRADE Research Group

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Neuropathology of AD starts approximately 1520 years prior to its clinical symptoms (Ashton et al., 2019)
