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Sildenafil works by inhibiting the enzyme PDE5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis

If diarrhea persists beyond a few days at any dose level, it may indicate that the dose escalation happened too quickly

[DOI] [PubMed] [Google Scholar] 9.Mavrogenis A.F., Angelini A., Pala E., Sakellariou V.I., Ruggieri P., Papagelopoulos P.J

Ermund et al., 2021)
