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Catecholamine receptors compensate by becoming more abundant and therefore more responsive to exogenous catecholamine-like drugs.

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doi: 10.1155/2012/724904

Increasing BH 4 supply Rationale As reviewed above, BH 4 deficiency is a common cause of eNOS uncoupling in many cardiovascular diseases (Figure 5) (Vasquez-Vivar et al., 1998