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DMB can mitigate foam cell formation and atherosclerotic plaque development by lowering TMAO levels

Components of the CS are both enzymes able to catalyze the acyl-CoA + carnitine CoA + acylcarnitines reaction and carrier(s) involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa

In TMAO-treated macrophages, significant upregulation is observed in both M1 signature cytokines (including IL-1, IL-6, TNF-, Chemokine (C-X-C motif) ligand (CXCL) 9, and CXCL10) and key genes such as NLRP3 (77)

NIH and Office of Dietary Supplements grants HL103866, HL126827, and DK106000, and the Leducq Foundation