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A meta-analysis evaluating 13 studies and a total of 4155 people with COPD concluded that the standard dose of 1200 milligrams of N -acetylcysteine per day reduces the incidence and severity of flares (known as exacerbations) compared to a placebo [104]

Moreover, it modulates GSH levels by regulating its synthesis through direct gamma-glutamylcysteine ligase and glutathione synthase transcriptional control[41,43]

For patients who want to combine the two, the injection cadence is manageable

Moreover, a dietary background including every-day cooking habits may influence the outcomes of vitamin supplementation via food fortification (vitamins of the B group), the natural content of the isoforms of a vitamin in oils (vitamin E), or a high consumption of vitamin-rich food (vitamin A and D in cold-water fish)