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In addition, elevated blood pressure may induce mechanical stress in the peritubular capillary network and mechanical shear stress

Recommendation Genetic testing for HFE p.Cys282Tyr and p.His63Asp should be offered to all individuals particularly those of European descent having both raised serum ferritin and transferrin saturation, individuals with an isolated elevated serum ferritin or transferrin saturation where there is no other cause identified, and first-degree relatives of individuals with HFE-related hemochromatosis (HIGH QUALITY of EVIDENCE

Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Sang-Yong K, et al

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