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1,25-Dihydroxyvitamin D3 reduces TGF-3-induced fibrosis-related gene expression in human uterine leiomyoma cells

These natural products generally exhibit convergent activities aimed at restoring redox balance, suppressing inflammation, inhibiting apoptosis, and promoting tissue repair

Inhibition of this pathway under normal conditions phenocopied a hyperglycemic state by enhancing chemotherapeutic efficacy in mouse PDAC, while rescuing the pathway under high glucose abrogated the anti-tumor effects observed with chemotherapy

Acknowledgements We thank Junko Sato and Mayumi Suda and the Biomedical Research Unit of Tohoku University Hospital for technical assistance with the experiments