adenocarcinoma glutathione in Cancer Cell Death Frontiers | A prognostic signature

IDH1 mutations cause significant changes in enzymatic reactions, catalyzing the large-scale conversion of -ketoglutarate (2-KG) to 2-hydroxyglutarate (2-HG), and cause significant changes in the cells metabolic system

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It is suggested that iron plays an important role in inducing autophagic cell death after cerebral hemorrhage, and this effect may be one of the secondary injury mechanisms of the brain ( 2 O 2 produced by oxidative stress can bind to the cysteine 81 site of ATG4 to regulate the activity of ATG4 (Scherz-Shouval et al., 2007), then enhance autophagy and cause autophagic cell death (Koike et al., 2008)

Additional mechanisms