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As a feedback response, MYB4 interacts with HY5, preventing its binding to MYB4 promoter, thus finely regulating its expression to balance light and cytokinin signals in controlling hypocotyl growth during Arabidopsis seedling development

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It is important to note that there are developmental differences in hepatic metabolism that may affect the hepatotoxicity seen in infants and young children

Regarding oxidative stress regulation, exercise can activate the Nrf2/ARE pathway, upregulating Nrf2 expression to promote SOD activity and reduce oxidative stress markers like MDA, exerting a protective effect [68-70]