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Description
In obese adipose tissue, excessive ROS production from NADPH oxidases and impaired ETCs induces mitochondrial DNA (mtDNA) damage, which escapes into the cytoplasm and circulation as damageassociated molecular patterns (DAMPs), activating TLR9 and NLRP3 inflammasome pathways to trigger proinflammatory cytokine cascades such as IL1 and IL18 [118, 119]
Used for diagnosing sleep apnea and other disorders
Denman WT, Ballantyne J
10.1007/s10517-017-3640-2 25 DuanJ
