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By contrast, the expression of mitochondrial fusion protein Mfn2 decreased in both in vivo and in vitro ischemic models, and reduced Mfn2 expression led to mitochondrial dysfunction and disruption of Ca 2+ homeostasis [49, 50]
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First, we confirmed the ability of WZ-1 to induce recombinant WDR5 protein oligomerization in vitro using immunoblotting

Hence, once the expression of Pink1 in the brain, especially in the substantia nigra, is knocked out in monkeys, the development of loss of dopamine neurons in the substantia nigra should be a clear consequence
