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Curcumin remarkably reduces malondialdehyde (MDA) and nitrotyrosine levels and induces superoxide dismutase (SOD) and glutathione peroxidase (GPx) post-TBI (Hakiminia et al., 2022)

These enzymes are responsible for the metabolism of B(a)P to a carcinogenic compound BPDE [benzo(a)pyrene-7,8-diol-9,10-epoxide], and CYP induction is associated with damage to the DNA of spermatozoa and ROS overexpression (Revel et al., 2001), as here observed

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The newly synthesized IGF-I is then hypothesized to be released into the circulation, where it could act upon various target tissues