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Ferroptosis: a new antidepressant pharmacological mechanism
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A poorly functioning liver cannot absorb, transport properly, and store iron
Even more intriguing is the notion that GGT-mediated hydrolysis of GSH can create a low level of ROS, due to generation of the more reactive thiol cysteinylglycine, which can reduce ferric iron to ferrous iron and trigger an iron redox cycling with production of ROS (Paolicchi et al., 2002)
