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Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses

In contrast, more recent studies using CHO cells have demonstrated that THCV functions as a partial agonist at the cannabinoid receptors to inhibit cAMP formation and to stimulate arr2 recruitment (Zagzoog, et al., 2020)

In KS483 osteoblasts, ellagic acid and walnut extract both promoted the development of nodules (Papoutsi et al
