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The more direct published evidence currently available concerns VEGFR2 expression, VEGFR2-Akt-eNOS signaling, and Src-Cav-1-eNOS pathway activation rather than the complete transcriptional-to-secretory VEGF sequence

Serum vitamin B12 measurement forms the cornerstone of diagnosis, with levels below 148 pmol/L (200 ng/L) generally considered deficient, though symptoms can occur at higher levels

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In a 2020 study published in the International Journal of Trichology , individuals with prematurely graying hair were significantly more likely to have biomarkers of oxidative stress, including high levels of malondialdehyde and low levels of glutathione and superoxide dismutase