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SAM, a key methyl donor, is derived from folate/one-carbon metabolism and the methionine cycle, with its levels regulated by mitochondrial metabolism, thereby controlling the supply of methylated substrates [250]

Early tumor screening and diagnosis are key for effective treatment and favorable prognosis

The two key roles of these enzymes are to activate and regulate thyroid hormones, which regulate metabolic functions in the body

Further studies should now focus on non-inferiority studies comparing these new oral molecules against currently recommended injectable GLP-1 RAs to have a clear comparison between these families of medications
