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Hibuscus Sabdariffa suppresses the expression of inflammatory cytokines, including IL-6 and TNF- in dextran sodium sulphate-induced colitis.[25] Glycyrrhiza glabra maintains the integrity of the intestinal epithelium via HuR in IEC-6 cells.[26] Althea officinallis decreased TNF-a and IL-1b and promotion of mucin, NO, PG-E2, and PG-12[27] Zingiber officinale m odulates nuclear factor-B activity and interleukin-1.[28] Plantago lanceolate inhibits the enzymatic activity of inducible nitric oxide synthase expressed in both macrophages and neutrophils and 5 lipoxygenase [29] Medicinal mushrooms are a viable source of prebiotics as they contain different polysaccharides, such as chitin, chitosan, hemicellulose, xylans, mannans, galactans, and - and -glucans

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