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Cannabis use patterns, which are prevalent in this population but rarely assessed systematically, may represent an additional and underappreciated source of heterogeneity, motivating the present studys integration of detailed cannabis phenotyping and 7T 1 HMRS measurement

The underlying mechanism is as follows: oxidative phosphorylation, the TCA cycle, and the electron transport chain face inhibition due to an inadequate oxygen supply to brain tissue, alongside mitochondrial damage and dysfunction, leading to a marked decrease in ATP synthesis and overall energy metabolism impairment

Trevino PLOS ONE.2015