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Suppression of Cx43 hemichannels via intrathecal injection of blockers such as Gap26, Gap27 or Peptide 5 reduces the production of chemokines CXCL1 and CXCL12, as well as cytokines IL-1 and IL-6, in various neuropathic pain models, including nerve injury, chemotherapy-induced and bone cancer models 496,498,504,505

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Upregulates growth hormone receptors (GHr): Increasing tissue sensitivity to natural GH

The broader copper peptide network The paper also notes that copper peptide complexes (including the related GHK-Cu) are known to increase VEGF (vascular endothelial growth factor) production and decrease TGF-1 secretion by dermal fibroblasts