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Moreover, 4F activates small G protein and its downstream janus kinase-2 (JAK2)/signal transducers and activators-3 (STAT3) signaling pathway through ABCA1, acting vital roles in macrophage activation 144

If you are seeing black pigmentation on your tongue that is new or changing, do not panic - but do prioritize getting a clinical evaluation rather than waiting to see if it changes on its own

This condition predominantly affects the gingiva, hard palate, and buccal mucosa, with the severity of pigmentation directly proportional to the cumulative exposure to tobacco

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