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NAA interacts with the rate-limiting enzyme of pyrimidine nucleotide biosynthesis, which is a trifunctional enzyme encoded by the CAD gene
Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS
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The nanoparticles release KGF to decrease intrapulmonary ECM in fibrotic lesions, while MMP13 mRNA is delivered in integrinenriched myofibroblasts and injured AT2 cells to reepithelialize the disrupted alveolar epithelium, synergistically improving lung function and reversing pulmonary fibrosis in mice
