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Melatonin facilitates the nuclear translocation of the Nrf2 transcription factor and promotes its interaction with ARE, thereby amplifying the expression of antioxidant enzymes (Figure 2) (Rajput et al., 2017)
Chronic carbamazepine use has also been associated with decreases in bone mineral density and 25-hydroxy (OH) vitamin D
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154 This study highlights the Nrf2dependent antiinflammatory mechanism of PBM, suggesting its potential as a complementary AD treatment
