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Short term (minutes to hours) exposure to high irradiance blue light can cause damage to RPE cells (Tosini et al., 2016)

Recordings were made at room temperature in artificial cerebrospinal fluid (aCSF) (pH 7.3, osmolarity 305 +/- 5 mOsm/kg) perfused at 2 mL/min containing 150 mM NaCl, 10 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, 10 mM glucose, 3 mM potassium chloride, 2 mM calcium chloride, and 1.3 mM magnesium chloride

It is possible for the duration of the effects of a B12 injection to vary greatly among individuals

The most widespread explanation is that as normal cellular physiological and biochemical processes fail more frequently, dopaminergic neurons become more sensitive to toxic assault