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Description
We found that APR-017 or LCS3 treatment induced an increased level of ROS and a decreased level of GSH (presented as the ratio of GSH to oxidized form, GSSG) in VRK2-KO cells, but not VRK2-WT cells (Fig
Plasmid 105: 102436 (read) Delaux PM, Hetherington AJ, Coudert Y, Delwiche C, Dunand C, Gould S, Kenrick P, Li FW, Philippe H, Rensing SA, Rich M, Strullu-Derrien C, de Vries J (2019) Reconstructing trait evolution in plant evo-devo studies
There are three forms: SOD1 (cytoplasmic), SOD2 (mitochondrial), SOD3 (extracellular)

The supply of GSH precursors from astrocytes to neurons does not only increase the GSH content in neurons but also improves the resistance of neurons to various adverse treatments, including induction of oxidative stress and application of toxins (Table 2), demonstrating the importance of the astrocytic cysteine supply for neuronal GSH synthesis
