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nAChRs are ligand-gated ion channels composed of five transmembrane subunits, with the 4 2 receptor subtype being the most common in the brain, playing a crucial role in the behavioral effects of nicotine

Studies like NeoPAL and CORALLEEN suggest that aromatase inhibitors combined with CDK4/6 inhibitors provide similar long-term survival benefits compared to neoadjuvant chemotherapy but with slightly improved breast conservation rates and fewer chemotherapy-related adverse effects

Further analysis of such subsets may uncover treatable traits, or phenotypes and endotypes that may facilitate the recognition of patients who will benefit from certain therapies

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