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Such findings support a close link between oxidative damage and neuronal injury ( + , a metabolite transported into dopaminergic neurons via the dopamine transporter, accumulates in the mitochondria and inhibits complex I activity of the electron transport chain, reducing ATP production and increasing ROS release, ultimately causing degeneration of dopaminergic neurons in the substantia nigra and striatum ( 2.4 Relationship between aging and neurodegenerative diseases Given the high prevalence of neurodegenerative diseases in older adults, aging is considered the primary risk factor for neurodegeneration (53)

doi: 10.1038/s41419-020-2298-2 72 SuiSXuSPangD

Statements Author contributions QL and KW conceived and designed the scope of the review

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