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For many adults, this may be when they start to become sleepy

Clinical Status Human RCT | Observational | Animal | In vitro Primarily studied in preclinical and exploratory neurophysiological research contexts, with limited controlled human trials

PLoS One 10:e0130251 Afshar B, Ganjalikhani-Hakemi M, Esfahani ZK, Eskandari N, Shaygannajad V, Hosseininasab F, Alsahebfosoul F (2021) Evaluating the effects of epigallocatechin-3-gallate on HIF-1 protein and rorc gene expression in peripheral blood mononuclear cells in patients with multiple sclerosis