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Thus, the events in the rats after removal of the bilateral carotid artery ligation may be the followup of the observed activation of particular pathways with local and systemic relevance in the rats with ligation of the inferior caval vein receiving BPC 157 therapy (Vukojevic et al., 2018)

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More importantly, metformin, a commonly used antidiabetic drug, has also been shown to treat AIH by upregulating growth arrest and DNA-damage inducible 45 (Gadd45) expression and inhibiting JNK phosphorylation

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