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Bortezomib-induced peripheral neuropathy: clinical features, molecular basis, and therapeutic approach

Elevated glucocorticoid levels, along with decreased glucocorticoid receptor (GR) function in early AD, are linked to A production and abnormal tau phosphorylation (Figure 1)

Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

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