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Description
An association between ROS levels and IFN- response in HIV-1 infection has been reported, whereby HIV-1 reverse transcriptase enzyme-induced increased ROS levels induce stronger IFN- responses 115
The mechanism underlying this inhibition was attributed to the activation of the GADD45A/JNK pathway coupled to a substantial decrease in Wnt target genes (Cyclin D1;c-Myc)
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[DOI] [PubMed] [Google Scholar] Lemaire S., Michelet L., Zaffagnini M., Massot V., Issakidis-Bourguet E
