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For treatment of phBEC, fully differentiated cells were stimulated for 24 or 48 hours with 2 ng/ml TGF-1, 10 ng/ml TNF-, 10 M menadione from the apical (in 100 l HBSS) and basolateral side (in 1 ml ALI medium) simultaneously

Kim JK, Thompson H, Jimenez-Rodriguez RM, Wu F, Sanchez-Vega F, Nash GM, Guillem JG, Paty PB, Wei IH, Pappou EP, Widmar M, Weiser MR, Smith JJ , Garcia-Aguilar J

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At present, the clinical treatment of gouty arthritis aims to reduce UA and inhibit inflammation as the main method, and the treatment mechanism is singular, with patients often needing to take multiple drugs at the same time to control the disease (103)