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Activin A signals by binding to one of the two types II receptors on the cell surface (ActRIIA or ActRIIB), which leads to the enrolment of type I receptors ActRIB (ALK4), and to the activation of Smad-dependent or Smad-independent signalling pathways [18]

b , Local resolution and FSC curves for the single face-down NNTNADP + structure

Interestingly, ALS and frontotemporal dementia (FTD) are closely related conditions and often share both genetic and disease mechanisms, especially in people with C9ORF72 mutations suggesting they may be part of the same disease spectrum (Parobkova and Matej, 2021)

The embryos were morphologically evaluated under an inverted phase-contrast microscope (BX-60, Olympus, Tokyo, Japan)