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After treatment of drug-resistant tumor cell lines, MCF7/TH, HCT116R and A549/ADR, with curcumin, ROS levels and expression of apoptotic markers, such as Bax and cytochrome c, were notably increased in the high-dose group compared to the low-dose group (25)

Clin Endocrinol (oxf) 63:197202

However, the extent of these effects varies among studies due to differences in study design, dosage, intervention duration, and participant characteristics

As a result, patients frequently experience cognitive problems, levodopa-induced dyskinesias (uncontrolled, involuntary movements), and on-off fluctuations (periods when the medication is effective, followed by periods when it is not)