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Complex II, often referred to as succinate-coenzyme Q reductase, uses succinate to reduce coenzyme Q to QH2 using covalently bound FAD as a coenzyme to produce reduced flavin adenine nucleotides (FADH2) ( Figure 1 )
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Formation of a germinal center (GC), where B cells interact with specialized T follicular helper (TFH) cells, is an integral part of generating high-affinity antibodies, as the GC is the localized site where somatic hypermutation and affinity maturation of the antibody response occurs

PIs are essential for the recruitment of effector proteins like EEA1 and the membrane remodelling ESCRT complexes, which drive the progression of early phagosomes to the degradative lysosomal pathway to eliminate the pathogen 5
