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Nevertheless, occupational exposure to crystalline silica dust in industrial settings may lead to silicosis, characterized by lung inflammation and fibrosis [142]

VCN managed to halt the progression of fibrosis either directly by interfering with the classical TGF-1/Smad 2/3 signaling pathway or indirectly by upregulating the expression of Nrf2, enhancing the antioxidant system, activating PPAR- and downregulating the NLRP3/NF-B pathway which influences the production of inflammatory cytokines involved in the pathogenesis of pulmonary fibrosis

When mitochondria are damaged, they release increased amounts of ROS, further impairing themselves and other cellular organelles, and creating a vicious cycle [58]

Anthocyanins help attenuate the effects of high light stress (Zheng et al