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The efficacy of the checkpoint inhibitor immunotherapy is augmented in the presence of Bifidobacterium and Bacillus fragilis through the shaping of the host immune system (145, 146)
However, deficiencies can occur in individuals who have difficulty absorbing nutrients or those who follow vegetarian or vegan diets without supplementation
These physiological structures are the bloodbrain barrier (BBB) and the bloodcerebrospinal fluid barrier
