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Lee et al., 1999).The neuroprotective activity of ebselen has been attributed to its GPx-like activity (Suzuki, 2009)

Given the multifactorial and heterogeneous pathophysiology of tinnitus, which involves maladaptive neuroplasticity, inflammation, oxidative stress, and often comorbid psychological distress, a single-target pharmacological intervention is unlikely to be universally effective

Pretreatment without peptides was used as a negative control, while treatment with an anti-aging peptide, acetyl hexapeptide-8 (Wrinklend), was taken as a positive control

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