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Results observed in clinical trials may not reflect real-world outcomes

This review provides a comprehensive overview of glycine metabolism, the structural biology and transport cycles of SLC6 glycine transporters, and the neuroanatomical framework of GlyT1 function

A multicenter Phase III clinical trial confirmed that elagolix significantly reduces menstrual blood loss associated with uterine fibroids, with efficacy unaffected by age, body mass index, ethnicity, baseline bleeding volume, or fibroid location [160]

It is the principal upstream regulator of GnRH secretion, integrating sex hormone feedback to determine when and how frequently GnRH and downstream LH is released
