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A remarkable feature of cells undergoing apoptosis is that they rapidly and selectively release a large fraction of their intracellular GSH into the extracellular space [120,121]

Disruptions in circadian rhythms can adversely affect sleep quality and lead to imbalances in gut microbiota, resulting in alterations to the community structure, ecological parameters of the microbial ecosystem, and the inflammatory state of the body [45, 214,215,216,217,218,219,220,221]

While the latter does not respond to altered oxygen levels, under normoxic conditions, HIF-1 is degraded rapidly through the prolyl hydroxylase (PHD)/von Hippel-Lindau protein (VHL) pathway [38]

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