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Similar acute haemolytic attacks have been observed, predominantly in men of Afro-Caribbean origin, in response to primaquine and a variety of other drugs, including dapsone, the antipyretic acetylphenylhydrazine, the antibacterial bactrim/septrim, sulphonamides and sulphones, whose only common feature is that they all undergo cyclic non-enzymic reactions in the presence of oxygen to produce hydrogen peroxide and a variety of oxygen radicals that can cause oxidative damage to membrane lipids, leading to haemolysis

NPs, a distinct subclass of MPs, possess smaller dimensions, a larger surface-to-volume ratio, and greater chemical reactivity than MPs, enhancing their capacity to disrupt metabolism and impair reproduction in animals 15,16

LC also increased sperm motility, sperm survival, and reduced sperm morphology abnormality