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High levels of blood phosphorus (hyperphosphatemia) and anxiety may contribute to worsening RLS in renal disease patients

[DOI] [PMC free article] [PubMed] [Google Scholar] Itoh K, Tong K-I, et al

The proposed mechanism involves inhibiting serotonin reuptake in synapses, thereby prolonging elevated levels and enhancing its positive impact on mood regulation

Concerning the molecular mechanism of these promising neuroprotective effects, quercetin induced a marked elevation in GSH level and activities of antioxidant enzymes
